Blar i UiS Brage på forfatter "Tidwell, Tia R."
-
3D in vitro cancer models for drug screening: A study of glucose metabolism and drug response in 2D and 3D culture models
Tidwell, Tia R. (PhD thesis UiS;, Doctoral thesis, 2022-03)Current drug screening protocols use in vitro cancer cell panels grown in 2D to evaluate drug response and select the most promising candidates for further in vivo testing. Most drug candidates fail at this stage, not ... -
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines
Tidwell, Tia R.; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland (Peer reviewed; Journal article, 2022-05)Background Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the ... -
Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells
Alhourani, Abdelnour H.; Tidwell, Tia R.; Bokil, Ansooya Avinash; Røsland, Gro V.; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne R. (Peer reviewed; Journal article, 2021-05)Cancer cells exhibit altered metabolism, a phenomenon described a century ago by Otto Warburg. However, metabolic drug targeting is considered an underutilized and poorly understood area of cancer therapy. Metformin, a ...